Zymeworks Showcases Updated Clinical Data for Zanidatamab at the 2023 ESMO Annual Congress

Zymeworks is pleased to announce, along with our partners Jazz Pharmaceuticals and BeiGene, updated data from two ongoing clinical trials evaluating zanidatamab, a HER2-targeted bispecific antibody for the treatment of solid tumors, at the European Society of Medical Oncology (ESMO) Annual Congress taking place October 20-24 in Madrid, Spain.

Poster Presentation Information:

Title: Zanidatamab (zani) plus chemotherapy (chemo) and tislelizumab (TIS) as first-line (1L) therapy for patients (pts) with advanced HER2-positive (+) Gastric/gastroesophageal junction adenocarcinoma (GC/GEJC): updated results from a phase 1b/2 study
Author: Keun-Wook Lee, et al.
Date: Monday, October 23 at 12:00-1:00 pm Central European Summer Time (CEST)
Abstract Number: 1518P

The presentation features progression-free survival (PFS) and duration of response (DoR) results from a Phase 1b/2 study of zanidatamab plus chemotherapy in combination with tislelizumab for the first-line treatment of HER2-positive gastric/gastroesophageal junction adenocarcinoma (G/GEJC). The study, sponsored by BeiGene, Ltd., showed zanidatamab plus chemotherapy and tislelizumab produced antitumor activity with a confirmed objective response rate (ORR) of 75.8% and median PFS of 16.7 months; and safety was consistent with previous findings.

Title: Quality of life (QoL) outcomes in patients (pts) with zanidatamab (zani)-treated HER2-positive (HER2+) biliary tract cancer (BTC) in the Phase 2b HERIZON-BTC-01 study
Author: Harpreet Wasan, et al.
Date: Monday, October 23 at 12:00-1:00 pm CEST
Abstract Number: 101P

The presentation features quality-of-life data from a Phase 2b study of zanidatamab for the second-line treatment of HER2-amplified biliary tract cancers (BTC), finding that patients with HER2-positive BTC who responded to zanidatamab reported improved health-related quality of life (HRQoL) compared with baseline. Overall, zanidatamab led to a meaningful clinical benefit, which may reduce disease burden and potentially result in improved patient HRQoL compared with baseline.