Publications

Preclinical
Tumor Models Summit
January 29, 2025
Leveraging Humanized Mouse Models to Support T-Cell Engager Development
Nichole Escalante
Preclinical
Tumor Models Summit
January 29, 2025
TriTCE Co-Stim: A trispecific T cell engager platform with integrated CD28 co-stimulation to improve T cell function and anti-tumor responses in hard-to-treat cancers
Diana Canals Hernaez
Preclinical
PepTalk
January 15, 2025
Parallelization of Paratope Optimization and Antibody Format Screening for Efficient Characterization and Development of Multispecific T Cell Engagers
Meghan Verstraete
Preclinical, ZW171
SITC
November 9, 2024
Mechanistic QSP modeling and translational strategy for determining an FIH dose for ZW171, a bispecific 2+1 T-cell engager molecule targeting mesothelin and CD3
Charles Chen
Preclinical
PEGS
November 5, 2024
Trispecific T Cell Engagers Incorporating Conditional CD28 Co-stimulation (TriTCE Co-stim) to Improve Treatment Responses in Oncology
Nina Weisser
Preclinical
PEGS
November 5, 2024
Azymetric Fc-based Therapeutic Modalities Enabling Tumor-Restricted Immune Cell Activation and Engagement
Thomas Spreter von Kreudenstein
Preclinical
AACR-EORTC-NCI
October 25, 2024
ZW220, a NaPi2b-directed TOPO1i ADC, demonstrates compelling preclinical activity in NSCLC, ovarian and uterine cancer models, with a favorable toxicology profile in NHPs
Andrea Hernández Rojas
Preclinical
AACR-EORTC-NCI
October 24, 2024
Beyond ADC Target Expression: Understanding ADC Properties and Pharmacology
Raffaele Colombo
Preclinical
AACR, Cancer Discovery
October 23, 2024
The Journey of Antibody–Drug Conjugates: Lessons Learned from 40 Years of Development
Colombo et al.
Preclinical
AACR-EORTC-NCI
October 23, 2024
ZW251, a novel glypican-3-targeting antibody-drug conjugate bearing a topoisomerase I inhibitor payload, demonstrates compelling preclinical activity in hepatocellular carcinoma models
Madera et al.
Preclinical
World Bispecific Summit
September 4, 2024
Leveraging Azymetric to Optimally Format T-Cell Engagers and Bispecific ADCs
Preclinical
ACS
August 21, 2024
Design and selection of the novel camptothecin analog ZD06519: A payload optimized for antibody-drug conjugates
Brant et al.