Collaboration and licensing agreement with Celgene Corp. to develop bi-specific antibody therapeutics enabled using Zymeworks’ proprietary Azymetric™ platform. Under the terms of the agreement, Zymeworks and Celgene are collaborating on the research and development of multiple bi-specific antibodies with Celgene having the option to advance candidates into clinical development and commercialization. Zymeworks received an initial up-front payment as well as a significant equity investment from Celgene. Zymeworks is eligible to receive clinical, regulatory, and commercial milestones on successful candidates totaling up to US $164M per therapeutic candidate. Additionally, Zymeworks will receive royalties on worldwide net sales.
Cross-licensing and bi-specific antibody collaboration with Daiichi Sankyo to develop bi-specific antibody therapeutics enabled using Zymeworks’ proprietary Azymetric™ and EFECT™ platforms. Under the terms of the agreement, Daiichi Sankyo will acquire a license to the Azymetric™ and EFECT™ platforms to develop a bi-specific antibody therapeutic, for which Zymeworks will receive an upfront technology access fee and research support. Zymeworks will also be eligible to receive payments upon the achievement of preclinical, clinical and commercial milestones, as well as up to double-digit tiered royalties on global product sales. Additionally, Zymeworks will in-license immuno-oncology antibodies from Daiichi Sankyo, with the right to research, develop and commercialize multiple bi-specific products globally in exchange for royalties on product sales.
Collaboration and license agreement with GlaxoSmithKline (GSK) for the research, development, and commercialization of novel Fc-engineered monoclonal and bi-specific antibody therapeutics which have been optimized for specific therapeutic effects. Under the agreement, Zymeworks and GSK are collaborating to further develop Zymeworks’ Effector Function Enhancement and Control Technology (EFECT™) platform through the design, engineering, and testing of novel engineered Fc domains tailored to induce specific antibody-mediated immune responses. Both GSK and Zymeworks will have the right to develop and commercialize therapeutic antibody candidates incorporating Zymeworks’ optimized immune-modulating Fc domains. Zymeworks is eligible to receive pre-clinical, clinical, and commercial milestones of up to US $110 million per therapeutic candidate developed by GSK, as well as tiered sales royalties.
License agreement with GSK for the research, development, and commercialization of novel bi-specific antibodies enabled using Zymeworks' Azymetric™ platform. Under the agreement, GSK will have the option to develop and commercialize multiple bi-specific drugs across different disease areas. Zymeworks will receive upfront and preclinical payments of up to USD$36 million and is eligible to receive up to USD$152 million in development and clinical milestone payments, along with commercial sales milestone payments of up to USD$720 million, and tiered royalties on potential sales. As part of this second agreement, GSK has gained the right to combined the Azymetric™ platform with novel engineered Fc domains developed under the previously announced collaboration.
Eli Lilly & Co.
Collaboration with Eli Lilly and Company to develop bi-specific antibodies, using Zymeworks’ proprietary Azymetric™ platform, against multiple Lilly targets for immunotherapy and other applications. Under the terms of the agreement, Zymeworks has granted Lilly a worldwide license to the Azymetric™ platform to develop and commercialize therapeutic candidates in exchange for up to US $375 million in milestones and other payments, plus tiered sales royalties. In addition, Zymeworks received an initial up-front payment in the form of an equity investment.
Merck & Co.
Collaboration with Merck to develop bi-specific antibody therapeutics using Zymeworks’ Azymetric™ platform. Under the terms of the original agreement (2011) and the expanded collaboration (2014), Zymeworks has granted Merck, through a subsidiary, a worldwide license to develop and commercialize bi-specific antibodies generated through use of the Azymetric™ platform toward certain therapeutic targets. Both companies will collaborate to advance the technology platform and to progress bi-specific therapeutic antibody candidates in pre-clinical development with Merck responsible for clinical development and commercialization.