ZW49 Mechanism of Action

ZW49 can potentially mediate its therapeutic effect on HER2-expressing tumors through a combination of mechanisms, including:

  • cross-linked trans HER2 binding and HER2 receptor clustering;

  • increased HER2-mediated antibody internalization leading to:

    • enhanced toxin-mediated cytotoxicity and tumor growth inhibition;

    • enhanced HER2 downregulation;

  • increased maximum binding density and potent effector-function mediated cytotoxicity; and

  • enhanced blockade of ligand-dependent and ligand-independent tumor growth.

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