ZW33 Mechanisms of Action

ZW33 can potentially mediate its therapeutic effect on low HER2-expressing tumors by the bi-paratopic targeting of HER2 resulting in:

  • Increased HER2-mediated antibody internalization leading to:
    • Enhanced toxin-mediated cytotoxicity and tumor growth inhibition
    • HER2 downregulation
  • Increased maximum binding density and potent effector function-mediated cytotoxicity
  • Cross-linked trans HER2 binding and HER2 receptor clustering
  • Enhanced blockade of ligand-dependant and ligand-independant tumor growth
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