Structural Evaluation & Refinement

The protein engineering process initially involves a thorough understanding of the biological system of interest and involves an extensive system-related structure and data gathering effort that provides the groundwork for knowledge-driven model building and refinement. Different components in the ZymeCAD™ platform are applied to the resultant molecular model to calibrate a variety of biophysical characteristics compared to known experimental data about the system. The technique iteratively refines the quality of structural models using a tight integration of data and simulation-driven insights, providing a greater degree of realism for rational protein engineering.

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