Energy Function and Scoring

Zymeworks has developed and implemented proprietary energy and scoring functions that score and rank the stability of proteins and binding energies across protein interfaces. The functional form and parameters of the energy functions used by Zymeworks are calibrated against known experimental data and address a number of physically relevant interaction propensities of the protein and aspects of enthalpy, entropy and free energy. This empirical ranking has been successfully employed in the development of Zymeworks' platform technologies and protein therapeutics.

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