ZW33 Mechanisms of Action
ZW33 can potentially mediate its therapeutic effect on low HER2-expressing tumors by the bi-paratopic targeting of HER2 resulting in:
Enhanced toxin-mediated cytotoxicity and tumor growth inhibition due to increased HER2-mediated ADC internalization;
Increased ZW33-mediated HER2 internalization, which reduces HER2-mediated signaling and results in tumor growth inhibition and apoptosis;
Enhanced effector function-mediated cytotoxicity including ADCC, CDC and ADCP as a result of increased binding/decoration of the tumor cells by ZW33. Enhanced phagocytosis and presentation of HER2 antigen may also lead to increased immune targeting of the tumors; and
Increased blockade of ligand-dependent and ligand-independent tumor growth.